Phosphorylated IRS proteins
act as docking sites for several intracellular proteins such as Grb2, NcK and the regulatory subunit p85 of phosphatidylinositol 3-Kinase (PI3K), which mediate different actions of insulin.
Important signaling molecules downstream of IRS proteins
and Shc include MAPK and PI3K (Saltiel et al.
Topics featured will include: The Role of PKB in Cell Transformation and Cancer; Development and Therapeutic Potential of PI 3-Kinase Inhibitors; Insulin/IGF-1 Signalling and Lifespan; Serine Phosphorylation of IRS Proteins
and Insulin Resistance; Development and Therapeutic Potential of PTP Inhibitors; and others for a total of 23 sessions.
It is possible that the interaction between JAK2 and IRS proteins
is mediated via a focal adhesion kinase, FAK (Zhu et al.