IRF9

IRF9

A gene on chromosome 14q11.2 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
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Type I IFN activates transcription of genes related to anti-microbial host defenses by acting through its receptor to induce nuclear translocation of a heterotrimeric complex, called IFN-stimulated gene factor 3 (ISGF3), the latter composed of signal transduction and activator of transcription 1 (Stat1), Stat2, and IRF9.
10) Thus, NOD1 activation of CXCL9, CXCL10, and CXCL11 transcription via type I IFN requires nuclear translocation of ISGF3, a complex composed of Stat1, Stat2, and IRF9.
Therefore, this unique set of genes is induced by P4 and IFNT in uterine LE/sGE that lack both STAT1 and IRF9 (Figure 2).
This process promotes generation of the ISGF3 transcription factor, a complex of STAT1, STAT2, and IRF9 that accumulates in the nucleus.