IRF6


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IRF6

A gene on chromosome 1q32.3-q41 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity. IRF6 appears to be a transcription activator.

Molecular pathology
IRF6 mutations are linked to non-syndromic orofacial cleft type 6, popliteal pterygium syndrome and van der Woude syndrome.
References in periodicals archive ?
To characterize the genomic structure of the porcine IRF6 gene, the mRNA sequences of porcine IRF6 gene (GenBank Accession Number: AF327368) was used to search for porcine homologues with high throughput genomic sequences (HTGS) in the porcine genomic databases by BLAST (http://blast.
The porcine IRF6 gene consist of seven exons, using porcine genomic DNA, seven primer pairs were designed for PCR amplification of DNA sequences including all exon regions of the IRF6 gene (Table 1).
The porcine IRF6 cDNA is 2,203 bp in length (GenBank Accession Number: AF327368) and contains a 1,404 bp open reading frame (ORF) encoding a 467-amino acid polypeptide.
To determine tissue distribution of the porcine IRF6 gene, reverse transcription quantitative PCR (RT-PCR) was applied to nine different tissue samples.