IRF5


Also found in: Acronyms.

IRF5

A gene on chromosome 7q32 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
References in periodicals archive ?
Overall, the top three genetic loci in their study were the HLA region, and the recently identified STAT4 and IRF5 loci.
In addition, boosting IRF5 levels might help to treat people whose immune systems are compromised.
Our results show that IRF5 is the master switch in a key set of immune cells, which determines the profile of genes that get turned on in those cells.
sup][15] IRF5 is expressed mainly in dendritic cells, monocytes and B cells and has an important role in interferon production.
Recent findings have revealed the strongest evidence of associations between variants in the human IRF5 locus and a wide range of autoimmune diseases.
Here, we constituted a case-control association study in order to investigate the contribution of variants located in IRF5 in NMO and MS susceptibility.
In addition, the current study failed to certify a significant association of IRF5 variants with MS.
In conclusion, although this is a preliminary study, our results indicate that genetic variants in the IRF5 gene may affect neither NMO nor MS in the Southeastern Han Chinese population.