IRF4

IRF4

A gene on chromosome 6p25-p23 that encodes a member of the interferon regulatory transcription factor (IRF) family, which is characterised by an unique tryptophan pentad-repeat DNA-binding domain. IRF4 is lymphocyte specific and negatively regulates Toll-like-receptor (TLR)-signalling, which is central to activating the innate and adaptive immune systems.

Molecular pathology
A chromosomal translocation involving IRF4 and the IgH locus, t(6;14)(p25;q32), has been linked to myeloma.
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The adrenaline signaling pathway and transcriptional signaling by FoxOl and IRF4 have been reported to activate ATGL and HSL (Eguchi et al.
Transcriptional control of adipose lipid handling by IRF4.
Expression profile of MUM1/ IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas.
The research findings described in this media release can be found in the 5 December online issue of Leukemia, under the title, "Fas Apoptosis Inhibitory Molecule (FAIM) is up-regulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in Multiple Myeloma" by Jianxin Huo1, Shengli Xu1,2, Baohong Lin3, Wee-Joo Chng3,4,5, and Kong-Peng Lam1,2,6,7,8
Researchers have found that cells from a blood-borne cancer called multiple myeloma rely on the activity of a single protein, called IRF4, for the activation of a wide range of genes responsible for cell survival and spread.
Microscopy will demonstrate large B cells sequestered within the intravascular spaces; these cells inconsistently express several of the typical B-cell antigens, with CD79a, CD20, MUM1/ IRF4, and CD19 being the most commonly expressed.
Indolent lymphoplasmacytic and marginal zone B-cell lymphomas: absence of both IRF4 and Ki-67 expression identifies a better prognosis subgroup.
335) In PTCL-NOS, IRF4 translocation involved the T-cell receptor [alpha] locus (14q11.
1 - + EBER +/ - CD79a /+ + BCL-2 + - IgD - +/ IRF4 + - Fascin + - Abbreviations: EBER, in situ hybridization for Epstein-Barr virus;EMA, epithelial membrane antigen; IgD, immunoglobulin D; +, positive; -, negative; +/-, usually positive, may be negative; -/+, usually negative, may be positive.
IRF4 MUM-1 is an excellent marker expected to be strongly positive in Reed-Sternberg cells and can be used to highlight their presence, even though it is not at all specific and is also present in anaplastic large cell lymphoma.