IRF3


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IRF3

A gene on chromosome 19q13.3-q13.4 that encodes a member of the interferon regulatory transcription factor (IRF) family. IRF3 is inactive in the cytoplasm, but after serine/threonine phosphorylation forms a complex with CREBBP; the IRF3/CREBBP complex translocates to the nucleus and activates transcription of interferons alpha and beta, as well as interferon-induced genes.
References in periodicals archive ?
Arjun Rustagi, an MD/PhD student in the UW Medical Scientist Training Program, has developed a procedure to measure IRF3 activity in human blood cells.
This new methodology will be used to measure IRF3 function over the course of HIV infection-from the early stages of acute infection to the later stages of chronic infection that lead to AIDS.
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF3.