IRF3


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IRF3

A gene on chromosome 19q13.3-q13.4 that encodes a member of the interferon regulatory transcription factor (IRF) family. IRF3 is inactive in the cytoplasm, but after serine/threonine phosphorylation forms a complex with CREBBP; the IRF3/CREBBP complex translocates to the nucleus and activates transcription of interferons alpha and beta, as well as interferon-induced genes.
References in periodicals archive ?
STING has 5 possible transmembrane domains; if STING is present in the endoplasmic reticulum, it can activate both NF-kP and IRF3 and induce the expression of type-I IFN (46,47).
Expression of type-I IFN depends on the activation of IRF3 and IRF7 via IKK epsilon and TBK1.
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF3.
The research expanded on an earlier discovery by the Gale lab that HIV directly antagonizes the early innate immune response in infected cells by impairing IRF3 function.
The new studies found that the HIV protein vpu specifically binds to the immune protein IRF3 and targets it for destruction, thereby, preventing IRF3 from functioning to trigger an immune response within the infected cell.
This knowledge can be used to design new HIV antiviral therapeutics that prevent vpu from interacting with IRF3 and targeting it for destruction, thus enhancing immunity.
Arjun Rustagi, an MD/PhD student in the UW Medical Scientist Training Program, has developed a procedure to measure IRF3 activity in human blood cells.