IRF2


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IRF2

A gene on chromosome 4q34.1-q35.1 that encodes interferon regulatory factor 2, a protein of the interferon regulatory transcription factor (IRF) family, which competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes whose transcription is activated by IRF1.
References in periodicals archive ?
In ewes, IFNT induces expression of IRF2, a potent suppressor of transcription, which silences transcription of ESR1.
2[alpha]]) that stimulate angiogenesis and erythropoiesis; vi) hydroxysteroid dehydrogenase 11B (HSD11B1) that mediates corticosterone metabolism and expression of glucocorticoid recetors (GCCR); vii) synthesis of prostaglandins (PTGS2) ; and viii) IRF2 a potent repressor of transcription (Bazer et al.
Classical ISGs are expressed by maternal immune cells, as well as uterine GE and SC that do not express IRF2 and therefore respond to IFNT via the classical JAK/STAT cell signaling pathway (Figure 2).