IRF8

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IRF8

A gene on chromosome 16q24.1 that encodes interferon consensus sequence-binding protein (IRF8), a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
References in periodicals archive ?
The researchers discovered that downregulation of IRF-8 (meaning that the gene produces less IRF-8 protein) increases the production of cells called osteoclasts that are responsible for breaking down bone.
The genome-wide study showed that the expression of IRF-8 was reduced by 75 percent in the initial phases of osteoclast development.
The genetically engineered mice deficient in IRF-8 had decreased bone mass and severe osteoporosis.
The researchers concluded that IRF-8 suppresses the production of osteoclasts.