ERN1

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ERN1

A gene on chromosome 17q24.2 that encodes the ubiquitously expressed endoplasmic reticulum (ER)-to-nucleus signalling 1 protein, which has intrinsic kinase and endoribonuclease activities and plays a key role in altering gene expression in response to endoplasmic reticulum-based stress signals. ERN1 senses unfolded proteins in the ER lumen, leading to enzyme auto-activation; the active endoribonuclease domain splices XBP1 mRNA, generating a new C-terminus and converting it into a potent unfolded-protein response transcriptional activator, triggering growth arrest and apoptosis.
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76) One of these ER receptors, IRE1a, accounts for the pro-inflammatory potential of the UPR by recruiting TRAF2 to the ER membrane and thus the activation of NF-[kappa]B and the production of IL-6.
Endoplasmic reticulum stress--induced IRE1a activation mediates cross-talk of GSK-3[beta] and XBP-1 to regulate inflammatory cytokine production," Journal of Immunology, vol.
ELUCIDATING THE ROLE OF THE PRO-SURVIVAL TO PRO-DEATH MOLECULAR SWITCH IN THE IRE1A SIGNALING PATHWAY IN ARABIDOPSIS THALIANA.
2011) Involvement of IRE1a signaling in the hippocampus in patients with mesial temporal lobe epilepsy.