IRAK1


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IRAK1

A gene on chromosome Xq28 that encodes interleukin-1 receptor (IL1R)-associated kinase 1, one of two putative serine/threonine kinases which associate with IL1R after stimulation. IRAK1 is partially responsible for IL1-induced upregulation of transcription factor NF-kappa B.
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Gene symbol Gene name RS ID Alleles IRAK1 Interleukin-1 receptor- rs1059702 A/G associated kinase 1 SH2B3 SH2B adaptor protein 3 rs3184504 T/C MMEL1 Membrane rs3748816 T/C metalloendopeptidase-like 1 Gene symbol Minor allele cDNA location Genomic Exon frequency location IRAK1 0.
Our long-term goal is to develop drugs that target IRAK1 for a novel combination approach, to efficiently trigger apoptosis in recurrent metastatic cancer cells.
Our results demonstrated that the expression levels of TLR9, MYD88, IRAK1, and NF-[kappa]B were not affected by different levels of HBV DNA, whereas TRAF6 was decreased in the patients with lower HBV DNA copy numbers.
Chandra Mohan, professor of internal medicine and senior author of the study, said that identifying IRAK1 as a disease gene may also have therapeutic implications.
Our work also shows that blocking IRAK1 action shuts down lupus in an animal model.
He also said that locating IRAK1 on the X chromosome also represents a breakthrough in explaining why lupus seems to be sex-linked.
Although researchers had found an association between lupus and IRAK1 in previous genetic studies, they failed to find a definite link.
For the current study, the researchers studied five variations of the IRAK1 gene in the subjects, and found that three of the five variants were common in people with either childhood-onset or adult-onset lupus.
For further testing of the link, they took mice of a strain that normally were prone to developing lupus, and engineered them to lack the IRAK1 gene.
It was found that when IRAK1 was absent, the animals lacked symptoms associated with lupus, including kidney malfunction, production of autoimmune antibodies and activation of white blood cells.