ITPR1

(redirected from IP3R)
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ITPR1

A gene on chromosome 3p26.1 that encodes an intracellular receptor for a so-called second messenger (inositol 1,4,5-trisphosphate (IP3)) which, once stimulated by IP3, mediates calcium release from the endoplasmic reticulum. The three IP3 receptor subtypes—IP3R1, IP3R2 and IP3R3—are present in the wild as homo- and heterotetramers, are associated with calmodulin and FK506-binding protein, and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

Molecular pathology
IPTR1 mutations cause spinocerebellar ataxia type 15.
References in periodicals archive ?
They discovered a sub-type of IP3R, or IP3R3, to be very active among brain cancer patients and that caffeine stymies the spread of such compounds, resulting in less tumour growth in the brain and blocks cancer cells from spreading to other parts of the body, reports Xinhua.
Sequence comparison and biochemical assays have demonstrated that dry is the sole ryanodine receptor of the fly [83], dip codes for the only Drosophila IP3R [83], and PORIN has analogous functions to vertebrate VDAC1 [84].
2+] regulator proteins settled in the MAMs like IP3R, and VDAC and the uniporter mitochondrial [Ca.