Data presented at AACR describe the activities of ARIAD's compound, AP23994, which inhibits
the protein Src and related enzymes, in mouse models of ovarian cancer and Ewing's sarcoma (a form of bone cancer).
Ambit found that two drugs in clinical development for non-small cell lung cancer (NSCLC), EKB-569 and CI-1033, inhibit
the EGFR kinase with the T790M mutation.
The study should prove whether or not the drug inhibits
the creation of new vessels in the human eye, D'Amato contends.
In the study, five NEUGENE antisense drug candidates were evaluated for their ability to inhibit
replication of dengue virus in mammalian cell culture.
The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit
IRF-3 and beta interferon promoter activation.
Therefore--and in light of accumulation of the musks in human tissue--research is needed to determine if the musks similarly inhibit
the human efflux transporters, thereby compromising this defense against toxicants.
ANSWER: There is a range of substances in foods that either enhance or inhibit
the absorption of dietary iron.
Gliatech is developing a family of ADCON(R) products to inhibit
surgical adhesions following surgery.
Silver and chlorhexidine act synergistically to inhibit
microbial colonization of the device post-implantation by permeating bacterial cell walls and binding bacterial cell proteins.
Anti-inflammatory compounds like aspirin and indomethacin can inhibit
tumor promotion and have been linked to a reduced risk of colorectal cancer in humans.
In the study, scientists from Cell Therapeutics developed and, in collaboration with the University of Minnesota and University of California Los Angeles, screened CT-2576 and other synthetic small molecule compounds known to be inhibitors of phosphatidic acid against a reporter gene expression system for their ability to inhibit
HIV- expression in the chronically HIV-infected promonocyte U1 cell line.
Gypsum Panels Actively Inhibit
Mold and Provide Ease of Installation