Influenza virus NS1 protein inhibits
pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.
In this article, we demonstrate that Pb(II) and Fe(II), and to a lesser degree Cd(II), inhibit
Ape1 nuclease activity, unveiling a novel molecular target for these environmental metals.
In contrast, rofecoxib did not inhibit
the growth of the prostate-tumor cells.
495] was located in the calcium-calmodulin binding domain of eNOS, and phosphorylation of this Thr residue has been shown to inhibit
eNOS activity (Fulton et al.
AgION Technologies, located in Wakefield, Massachusetts, is a leader in providing customized, natural, antimicrobial solutions based on silver that continuously inhibit
the growth of bacteria, mold and fungus.
Zheng and his team suggest that when rapamycin inhibits
TOR, it works by eliciting a number 'of responses such as those of stress and starvation.
3+] at a concentration of 25 [micro]M did not inhibit
SNP-induced relaxation but did inhibit
acetylcholine-induced relaxation, suggesting that 25 [micro]M [As.
As early as 1972, another group of scientists found test-tube evidence that acetaminophen could inhibit
COX enzymes--which had yet to be subdivided into COX-1 and COX-2--in brain cells.
The half-maximal effect of BzATP was nearly 10 times lower than the half-maximal effect of ATP to inhibit
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The drugs inhibit
a single enzyme, and "they presumably won't work for other leukemias.
Currently in Phase 2 clinical trials, GX15-070 is a small molecule specifically designed to inhibit
all relevant members of the Bcl-2 protein family, a validated cancer target, thus restoring the natural cell death process of apoptosis.