ING3

ING3

A gene on chromosome 7q31 that encodes inhibitor of growth (ING) family member 3, a component of the NuA4 histone acetyltransferase (HAT) complex involved in transcriptional activation of genes, principally by acetylating nucleosomal histones H4 and H2A. Acetylation alters nucleosome-DNA interactions and upregulates transcription. The NuA4- HAT complex may be required for activating transcriptional programs linked to oncogene- and proto-oncogene-mediated growth induction, tumour-suppressor-mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a role in DNA repair when recruited to sites of DNA damage.
 
Molecular pathology
Defects of ING1 have been linked to an increased susceptibility to squamous cell carcinoma of the head and neck.
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7] Precio y otros 7,6% TABLA III DETERMINANTES DEL LUGAR DE COMPRA DE CARNE DE RES/ DETERMINANTS OF THE PLACE OF PURCHASE OF BEEF Variables Coeficientes Error Estandar INTERCEPTO 0,063007 0,475958 SEX 0,063369 0,220385 ING2 0,446106 0,236781 ING3 1,09021 0,32054 ING4 0,687117 0,329301 PAGO -1,51705 0,256534 NMEMB2 -0,054266 2,38785 NMEMB3 -0,343443 0,329693 NMEMB4 -1,47023 0,560511 PORQUE2 0,404634 0,305747 PORQUE3 -0,622047E-02 0,412321 PORQUE4 1,32319 0,390158 PORQUE5 -1,07997 0,536450 PORQUE6 0,068994 0,370385 PORQUE7 -0,182354 0,453021 TRAB2 -0,346786 0,293287 TRAB3 1,04825 0,302117 TRAB4 0,624965 0,290528 Log-verosimilitud -314,19 Log-verosimilitud maximo -387,17 restringido LR-jicuadrado (todos los 145,97 coeficientes, excepto la constante son iguales a cero) [R.