IL8


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IL8

A gene on chromosome 4q13-q21 that encodes interleukin-8, a cytokine belonging to the CXC chemokine family. IL8 is a major mediator of inflammation, acting as a chemoattractant for neutrophils, basophils and T-cells, and is a potent angiogenic factor.

Molecular pathology
IL8 is a candidate gene for bronchiolitis.
References in periodicals archive ?
IL8 and IL6 investigated for the relationship between periodontopathic bacteria (Aa &Pg) and bleeding on probing which shows that association is found in both aggressive and severe form of chronic periodontitis.
In a similar animal study the increased levels of IL6, IL8 and LPO (lipoperoxide) in smokers with chronic bronchitis is compared with non-smokers.
After washing five times with 200 [micro]l PBS containing 1 ml/ liter Tween 20, we incubated 100 [micro]l/well with PBS containing 1% BSA and a 1 : 1000 dilution of goat anti-human BD2 (Santa Cruz Biotechnology) or rabbit anti-human BD4, IL6 or IL8 (Santa Cruz Biotechnology) at room temperature for 2 h.
Exposure to different concentrations of shellac extraction product did not induce any changes in the release of IL8 compared to the untreated control, whereas the positive control (TNF) induced a clear inductive response (data not shown).
Se ha observado que Tricchophyton mentagrophytes aumenta la produccion in vitro de IL8 y de factor de necrosis tumoral alfa, lo cual explica la respuesta inflamatoria aguda causada por este dermatofito (53).
Ademas se activan los macrofagos, los cuales incrementan la produccion de citocinas, que intervienen en la informacion intercelular, las cuales se unen a receptores especificos de las celulas blanco, desencadenando la sintesis y liberacion de mediadores secundarios como factor activador de plaquetas, IFN, IL8, IL9, IL10 e IL13 que inducen la produccion de oxido nitrico, el cual produce vasodilatacion, produccion de prostaglandinas y leucotrienos, bradiquinina e histamina que a su vez activan macrofagos, polimorfonucleares e inicia un circulo inflamatorio.
IL8 and IL-1ss /TNF- a also showed increased production of nitrite than the con-trolled cells.
Newborn infants display a higher percentage of IL6 and IL8 positive cells than do adults.
These cytokines include interleukins (IL) 1p and IL8 as well as tumour necrosis factor alpha (TNF-[alpha]).
Production of IL6 and IL8 by FLS: Both IL-[beta] and TNF-[alpha] significantly increased the production of IL6 over baseline by 15--and 8.
por la sigla en ingles de nuclear factor) en fagocitos mononucleares, neutrofilos y celulas dendriticas y estimular la produccion de IL-6, IL8 y TNF-[alfa].
The assay sensitivities of IL-1[beta], IL-6, IL-10, IL-12p70, TNF-[alpha], IL8, MIG, IP-10, MCP-1, RANTES, and IFN-[gamma] are 2.