IL7


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IL7

A gene on chromosome 8q12-q13 that encodes interleukin-7, a hematopoietic growth factor which stimulates the proliferation of lymphoid progenitors, including both B and T cells. It forms a heterodimer with hepatocyte growth factor to act as a pre-pro-B-cell growth-stimulating factor. It is also a cofactor for V(D)J rearrangement of the T-cell receptor beta during early T-cell development. IL7 is produced locally by intestinal mucosal cells, and may act as a regulatory factor for intestinal mucosal (GALT) lymphocytes.
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Army Corps of Engineers (Corps) made tough decisions that thrust the town of Cairo, IL7 and the communities in southeast Missouri into the national spotlight, while also raising the question: How much value do we truly put into American agriculture?
JAK-3 is a cytoplasmic protein tyrosine kinase (involved in signaling through the common gamma chain of several cytokine receptors: IL2, IL4, IL7, IL9, IL15, and IL21) in many hematopoietic cells, including B cells, T cells, and NK cells.
Recent associations with IL2 and IL7 receptor are significant and appealing with respect to possible disease mechanisms, but account for less than 2% of MS genetic susceptibility.