IL6


Also found in: Dictionary, Financial, Encyclopedia, Wikipedia.

IL6

A gene on chromosome 7p21 that encodes interleukin-6, a cytokine which plays a role in the acute-phase response of inflammation and in B-cell maturation. It is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through Il-6 receptor alpha.

Molecular pathology
IL6 dysfunction is linked to increased susceptibility to diabetes and juvenile rheumatoid arthritis.
References in periodicals archive ?
Cole said: "The IL6 gene controls immune responses but can also serve as 'fertilizer' for cardiovascular disease and certain kinds of cancer.
The main finding of the present study was that the IL6 promoter SNP -174G/C showed association with V[O.
This is the first report providing evidence of the complementarity of these two natural products in decreasing the inflammatory response of both human monocytes/macrophages (TNF-[alpha], IL1, IL6, 1L8, 1L-10, [PGE.
Figure 4A shows that the greatest variation was attributable to the donor, although separation was observed a) by anticoagulant (Figure 4B), with citrate resulting in higher levels of IL2 and IL6 and heparin resulting in higher levels of IL8 (results not shown), and b) by bench time (Figure 4C), with the 8-hr and 24-hr time points deviating the most from the earlier ones, which were relatively similar.
Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-alpha, interleukin (IL)-1beta, IL6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis.
Drugs (or isolated biologicals in clinical use or trials): IL1, IL3, IL6, Stem Cell Factor(s), erythropoietin, G-CSF, etc.
Contracting muscle fibers produce and release IL6, and plasma levels of this cytokine are markedly elevated in response to physical exercise (Keller et al.
Located on chromosome 7p21, the IL6 [7] gene [interleukin 6 (interferon, beta 2)] contains 5 exons, and the IL6 coding sequence contains only a few very rare polymorphisms (http://genome.
Haplotype structure of inflammatory cytokines genes (IL1B, IL6 and TNF/LTA) in US Caucasians and African Americans.
This visceral fat has negative features; it secretes pro-inflammatory cytokines and adipokines such as TNF[alpha], IL6, adiponectin, leptin and others (de Ferranti and Mozaffarian 2008; Klein-Wieringa et al.
The effects of recombinant interleukin (IL)-lalpha, IL-lbeta or IL6 on the hypothalamo-pituitary-adrenal axis activation.
9) observed upregulation of mRNA in CD34-derived DCs for IL1[beta], IL6, IL8, CCL2, CCL3, CCL4, and CCL3L1 by sensitizers.