IL5


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

IL5

A gene on chromosome 5q31.1 that encodes interleukin-5, a cytokine which acts as a  growth and differentiation factor for B cells (inducing the terminal differentiation of late-developing B-cells to immunoglobulin secreting cell) and eosinophils, for the latter of which IL5 is a key regulator of eosinopoiesis, eosinophil maturation and activation.
References in periodicals archive ?
Cytokine/ Inflammatory Produced by Chemokine action IL4 pro/anti Macrophages, eosinophils, basophills IL5 pro/anti [T.
En contraste, los linfocitos Th2 promueven la inmunidad humoral y producen IL4, IL5 e IL10; los linfocitos Th2 suprimen la respuesta Th1 y estan asociados con la alergia.
The grant, entitled "Structure-based Design of Novel IL5 Receptor Antagonists," will enable SBI scientists to apply the company's proprietary protein modeling and dynamic pharmacophore-based searching of existing and virtual combinatorial libraries to rapidly identify and synthesize putative small-molecule interleukin-5 (IL-5) antagonists.
List of proteins analysed in Phase II samples: interleukin (IL)2, IL6, IL8, IL10, and tumor necrosis factor alpha, IL1[beta], IL4, IL5, IL7, IL13, interferon alpha, interferon gamma, eotaxin, fractalkine, interferon gamma-induced protein 10, granulocyte-macrophage colony stimulating factor, epidermal growth factor, fibroblast growth factor 2, granulocyte colony-stimulating factor, melanoma growth stimulatory activity/growth-related oncogene, monocyte chemotactic protein-1, monocyte chemotactic protein-3, macrophage derived chemokine, macrophage inflammatory protein 1 alpha, macrophage inflammatory protein 1 beta, soluble CD40 ligand, transforming growth factor alpha and vascular endothelial growth factor) using the milliplex HCYTOMAG-60SK and HSCYTMAG-60SK kits (Millipore, Billerica, MA).
Th2 cells secrete mainly IL4 and IL5 and participate in allergic reactions and in protection from metazoan parasites.
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, M5G IL5 Canada.
In addition, other Th2 cytokines besides HA, such as IL5 and IL13 that have been shown to be regulated by epigenetic mechanisms (Ho 2010; Webster et al.