IL4R

(redirected from IL4RA)

IL4R

A gene on chromosome 16p12.1-p11.2 that encodes the alpha chain of the IL4 receptor, a type-I transmembrane protein which can bind IL4 and IL13 to regulate IgE production. ILR4 also binds IL4 to promote differentiation of Th2 cells.

Molecular pathology
Allelic variants in IL4R have been associated with atopy, which is accompanied by allergic rhinitis, sinusitus, asthma and eczema, as well as by Japanese cedar pollinosis.
References in periodicals archive ?
Yuksek affiniteli IgE reseptorunu (FceRI; 11q13), mast hucre kimaz (14q11), IL4RA (interlokin 4 reseptor alfa zinciri, SPINK5 (serine proteaz inhibitor, Kazal tip 5), Toll benzeri reseptor 2 polimorfizmleri AD ile iliskili bulunmus mutasyonlardir.
Genegene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma.
Conversely, we found no association between the Ile50Va1 polymorphism in the IL4RA gene and HD severity (Table 1) despite the receptor activity being different among individuals with this polymorphism.