IL4R

IL4R

A gene on chromosome 16p12.1-p11.2 that encodes the alpha chain of the IL4 receptor, a type-I transmembrane protein which can bind IL4 and IL13 to regulate IgE production. ILR4 also binds IL4 to promote differentiation of Th2 cells.

Molecular pathology
Allelic variants in IL4R have been associated with atopy, which is accompanied by allergic rhinitis, sinusitus, asthma and eczema, as well as by Japanese cedar pollinosis.
References in periodicals archive ?
Secondary outcome measures include progression-free survival, overall survival, and exploratory predictors of outcome assessed by IL4R expression in archived tumor biopsies.
Assays used were as follows: TBP (endogenous control), Hs99999910_m1; CXCL16, Hs00222859_m1; IL4R, Hs00166237_m1; JUN, Hs00277190_s1; PF4, Hs00427220_g1; PTPRE, Hs00369944_m1; ZNF331, Hs00367929_m1.
IL4R and PF4 were chosen for confirmation from the cytokine subset because they were, respectively, the most significantly up-regulated and down-regulated cytokine genes for which TMGEAs were available at the time of this analysis.
Results for IL4R and PTPRE were less concordant, with increases in some pairs and decreases in others (Figure 1).
The six genes chosen for further study were CXCL16, JUN, PTPRE, ZNF331, IL4R, and PF4.