IL1B


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IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.
References in periodicals archive ?
Variants in LTA, TNF IL1B and IL10 genes associated with the clinical course of sepsis.
Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: A replication study.
Therefore, to understand the expression and regulation of PG transporters in porcine uterine endometrium during the estrous cycle and pregnancy, we evaluated i) expression of ABCC1, ABCC9, SLCO4C1, and SLCO5A1 mRNAs in the uterine endometrium during the estrous cycle and pregnancy, in the conceptus of early pregnancy, and in chorioallantoic tissues during pregnancy; ii) localization of ABCC1 and ABCC9 mRNAs in the uterine endometrium; and iii) effects of steroid hormones, IL1B, and interferon gamma (IFNG) on ABCC1, ABCC9, SLCO4C1, and SLCO5A1 mRNA expression in the endometrial tissues.
The capability of the cultures to respond to inflammatory inducers was tested in representative cultures per experimental repetition, in which a set of triplicate samples were treated for 24 h with a combination of TNFA and IL1B (10 ng/ml final concentration for each in the basolateral media).
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
In this case, several genes involved in cross talks between immune cells and cancer cells, such as C-C motif chemokine ligand 4 (CCL4), C-X-C motif chemokine ligand 2 (CXCL2), CXCL9, interleukin 15 (IL15), IL1B, or IL8 showed different expression levels between the individual CTCs captured via EpCAM or by size (see online Supplemental Fig.
The concentration of AST and ALT in the serum and the concentration of GSH, tumor necrosis factor (TNF), interleukin 10 (IL10), integrin alpha M (ITGAM, alias CDub), IL1B, MDA, nicotinamide adenine dinucleotide phosphate oxidase 4 (NO[X.
Surgical trauma induces an inflammatory state characterized by the release of pro-inflammatory cystokine IL1B.
It was also shown that identification of the IL1B variations tested brought extra value in predicting moderate to severe periodontitis above and beyond the risk attributable to smoking and diabetes alone.
However, the use of IL1B to modulate the immune response during vaccinations of animals and humans remains limited (Simbirtsev et al.
Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses.
IL1B polimorfizmi keratokonus olusturmak icin bir risk faktoru olarak gosterilmistir.