IL1B


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IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.
References in periodicals archive ?
Indeed, our preliminary studies have shown that levels of estrogen and IL1B, which are major embryonic signals at the time of pregnancy in pigs (Bazer et al.
This additional analysis has shown that specific genotype combinations of E4(-), IDE and IL1B produced additive improvements in cognitive performance.
Ninety saliva samples (27 from OSCC patients and 63 from matched controls) were assayed for 7 previously identified OSCC salivary RNAmarkers: SAT1, OAZ1,H3F3A, IL1B,IL8, DUSP1, and S100P (8).
This review and meta-analysis show that IL1A and IL1B genetic variations are significant contributors to chronic periodontitis in Caucasians," said Dr.
The level of transcripts encoding CYP19A1, FABP4, ICAM1, IGFBP3, IL1B, TRIB3, or VCANI1 was modulated only in precursors.
In addition to estrogen, conceptus produces IL1B into uterine lumen at the time of implantation in pigs (Jaeger et al.
This paper, from a collaborative team of international researchers, demonstrates that people with specific variation patterns in the IL1B gene had higher levels of IL-1Beta and C-reactive protein (CRP).
Another intriguing finding is that the haplotype that was associated with the highest level of IL1B activity was found far more commonly among African-Americans (46%) than in Caucasians (6%).
In the porcine uterus, elongating conceptuses secrete IL1B on D12 of pregnancy (Ross et al.
The first group of genes consisted of cytokine genes and genes related to cytokine signaling: TNF [5] [tumor necrosis factor (TNF superfamily, member 2)], IL1B (interleukin 1, beta), IL10 (interleukin 10), IL18 [interleukin 18 (interferon-gamma-inducing factor)], SOCS3 (suppressor of cytokine signaling 3), TGFB1 (transforming growth factor, beta 1), and IL6 [interleukin 6 (interferon, beta 2)].
These aliquots were analyzed for 4 genes: ACTB [7] (actin, beta), IL1B (interleukin 1, beta), CASP3 (caspase 3, apoptosis-related cysteine peptidase), and FGF7 [fibroblast growth factor 7 (keratinocyte growth factor)] in singleplex format.