IL-13


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Related to IL-13: IL-15, Il-4, Il-17

IL-13

abbreviation for interleukin-13.

IL13

A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.

Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.

interleukin

(in?ter-loo'kin),

IL

A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation

interleukin-1

Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor

interleukin-1-beta

Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin

interleukin-2

Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor

interleukin-3

Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor

interleukin-4

Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II

interleukin-5

Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil

interleukin-6

Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine

interleukin-7

Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor

interleukin-8

Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.

interleukin-9

Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.

interleukin-10

Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.

interleukin-11

Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor

interleukin-12

Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.

interleukin-14

Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.

interleukin-15

Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2

interleukin-16

Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.

interleukin-17

Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.
See also: interleukin
References in periodicals archive ?
In conclusion, the results of this study demonstrated the lower frequency of subjects with detectable levels of IL-13 in AMI group, higher serum levels of IL-17 in both AMI and UA groups and higher serum levels of IL-18 in IHD patients, especially UA groups.
Th2 cells produce granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-4, IL-5, IL-6, and IL-13, that promote, among other things, allergic inflammation and disease mediated by IgE antibodies.
6] cells/well) differentiated by the above methods were cultured with IL-4 (25 ng/ml) and IL-13 (25 ng/ml) for 24 h in a 60mm culture dish, and the differentiated M2 macrophages were then washed twice with Dulbecco's phosphate buffered saline (PBS) (pH 7.
beta]-actin, IL-17, IL-4 and IL-13 and IL-6, TGF[beta] primers were obtained from Sangon Company Primer express software (primer 5) was used to design primers from published cDNA sequences.
However, it was not associated with differences in the anti-inflammatory cytokines IL-10, TGF-[beta] and IL-13.
Newer therapies in asthma include omalizumab (an anti-IgE antibody), mepolizumab (an anti-IL5 monoclonal antibody), lebrikizumab (an IL-13 antibody) and the most recently studied dupilumab (a subcutaneously administered antibody to the alpha subunit of the IL-4 receptor which inhibits signalling by both IL-4 and IL-13).
We used real-time PCR to quantitate IL-13 and IL-17A mRNA expression as described (Shore et al.
Gene analysis of tumor tissues from the 5% BB-fed mice revealed significantly altered expression of genes important to inflammation, cancer, and metastasis, specifically, Wnt signaling, thrombospondin-2, IL-13, and IFN.
Higher levels of IL-6, CXCLi2 (IL-8), and IL-13 transcripts, but lower levels of IL-12 transcripts, were observed in the DECX and COBN groups compared with untreated controls (Figure 4).
H]2 cells appear important in limiting extracellular infections, especially parasites, and are especially important in allergic diseases and prototypically produce interleukin (IL) 4 and IL-13.
Higher stress was also linked with an increased IL-13 response to dust mite antigen, which has been associated with allergic sensitization in older children.
Results showed significantly lower levels of IL-5 and a trend towards decreased IL-13 levels in the probiotic group.