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Related to IL-13: IL-15, Il-4, Il-17


abbreviation for interleukin-13.


A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.

Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.




A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation


Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor


Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin


Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor


Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor


Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II


Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil


Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine


Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor


Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.


Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.


Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.


Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor


Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor


Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.


Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.


Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2


Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.


Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.


Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.


Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.
See also: interleukin
References in periodicals archive ?
As shown in Figures 8, the levels of IL-4 and IL-13 in OVA-sensitized and subsequently challenged offspring were significantly elevated in the lungs of the offspring, regardless of maternal exposure to air or N[O.
Lee YC, Lee KH, Lee HB, Rhee YK (2001) Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthma.
PMA-treated THP-1 macrophages were cultured with IL-4 (25 ng/ml) and IL-13 (25 ng/ml) to differentiate M2 macrophages in the presence or absence of the above two chalcones for 24 h in a 60-mm culture dish.
Otras terapias biologicas, como anticuerpos frente a IL-4, IL-5, IL-13, TNF-a o antagonistas de receptores de prostaglandinas, asi como agonistas de los receptores tipo toll 7 y 9, estan siendo investigadas para su posible uso en el asma alergica (Bice et al.
To determine the IL-4 role in inflammation, the expression of IL-4 mRNA was analyzed and the result showed that IL-4 and IL-13 gradually increased during RA (Figures 1A and 1B).
El objetivo general del trabajo fue relacionar la respuesta inmune humoral mediada por IgA e IgG local y sistemica y celular mediada por los LTCD4+ y las citocinas IFN-g e IL-2 (perfil TH1), IL-4, IL-5, IL-10 e IL-13 (perfil TH2) frente al peptido [PAc.
untreated controls in intestinal epithelia (CXCLi2, IL-4, IL-6, IL-13 IL-17F, IFN-[gamma], and TGF[beta]4) than in spleen cells (CXCLi2, IL-13, IL-17D, and IFN-[gamma]).
H]2 cytokine, from which it arose from a gene duplication event, IL-13 has been implicated in multiple effector mechanisms of [T.
Such response is supported by a high production of IL-13 and IL-10 followed by a low IL-12 production.
Results showed significantly lower levels of IL-5 and a trend towards decreased IL-13 levels in the probiotic group.
Th1 cells secret cytokines including interferon (IFN)-y and interleukin (IL)-2 whereas Th2 cells primarily secrete IL-4 and IL-10 and IL-13 (4).
Th-2 cells are associated with help for B cell antibody production and secrete IL-4, IL-5, IL-6, IL-10, and IL-13.