IL-10


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Related to IL-10: IL-2

IL-10

abbreviation for interleukin-10.

IL10

A gene on chromosome 1q31-q32 that encodes interleukin-10, a cytokine produced primarily by monocytes, but also by lymphocytes, which inhibits the synthesis of a number of cytokines (including IFN-gamma, IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and helper T cells. IL10 has pleiotropic effects in immunoregulation and inflammation. It downregulates expression of Th1 cytokines, MHC class-II antigens and co-stimulatory molecules on macrophages, and it enhances B cell survival, proliferation and antibody production. It can block NF-kappa B activity, and is involved in regulating the JAK-STAT signalling pathway.

Molecular pathology
IL10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.

interleukin

(in?ter-loo'kin),

IL

A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation

interleukin-1

Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor

interleukin-1-beta

Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin

interleukin-2

Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor

interleukin-3

Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor

interleukin-4

Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II

interleukin-5

Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil

interleukin-6

Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine

interleukin-7

Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor

interleukin-8

Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.

interleukin-9

Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.

interleukin-10

Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.

interleukin-11

Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor

interleukin-12

Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.

interleukin-14

Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.

interleukin-15

Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2

interleukin-16

Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.

interleukin-17

Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.

interleukin-10

Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.
See also: interleukin
References in periodicals archive ?
The assays for IL-2, IL-6, IL-10, and TNF-[alpha] (Seimens Healthcare Diagnostics Products Ltd.
01); in the CP group moderate correlation was observed between IP and MMP-8 and IL-10 (R=0.
Este estudio no encontro diferencias estadisticamente significativas en las concentraciones de biomarcadores perifericos (IL-1B, IL-RA, IL-2, IL-4, IL-6, IL-7, IL-8, IL-10, IL-12 y TNF) entre los subgrupos de pacientes con TBI (eutimia, depresion y eutimia) y el grupo control y tampoco se encontraron diferencias significativas cuando se compararon las cifras de IL del grupo con TBI y las del control.
Primers were used as follows: IL-5 for, 5'-AAAGAGAAGTGTGGCGAGGA GAGAC-3', rev, 5'-CCTTCCATTGCCCACTCTGTACTCATC-3'; IL-10 for, 5'-ATG CTG CCT GCT CTT ACT GAC TG-3', rev, 5'-CCC AAG TAA CCC TTA AAG TCC TGC-3'; IL-17 for, 5'-TTT AAC TCC CTT GGC GCA AAA-3' rev, 5'-CTT TCC CTC CGC ATT GAC AC-3'; IFN-[gamma] for, 5'-TCAAGTGGCATAGATGTGGAAGAA3', rev, 5'-TGGCTCTGCAGGATTTTCATG-3'; T-bet for, 5'-CCTCTTCTATCCAACCAGTATC-3', rev, 5'-CTCCGCTTCATAACTGTGT3'; GATA3 for, 5'-GAAGGCATCCAGACCCGAAAC-3', rev, 5'-ACCCATGGCGGTGACCATGC-3'; ROR[gamma]t for, 5'-ACAGCCACTGCATTCCCA GTTT-3', rev, 5'-TCTCGGAAGGACTTGCAGACAT-3'; Foxp3 for, 5'-CCC ATC CCC AGG AGT CTT-3', rev, 5'-ACC ATG ACT AGG GGC ACT GTA-3'; and GAPDH for, 5'-TGC AGT GGC AAA GTG GAG AT-3', rev, 5'-TIT GCC GTG AGT GGA GTC AT-3'.
Porem, evidencias sugerem que enquanto a IL-6 estimula a producao de Cortisol (Petersen e Pedersen, 2005), a TT inibe a expressao de IL-6 e potencializa a expressao da citocina anti-inflamatoria IL-10 (Bebo e colaboradores, 1999; D'Agostino e colaboradores, 1999), o que torna dificil compreender a interacao hormonio/citocina durante e apos o exercicio.
Se utilizo una prueba de inmunoabsorbencia ligada a enzima para la medicion cuantitativa de la IL-10 en cada muestra.
IL-10 concentration was higher immediately after and 60 min after both the 75% (p = 0.
According to the other researches, there is a straight relation between body fitness and IL-10 and also its increase in the body has been proved during sport.
Blood markers of interest included MIF, IL-6, IL-8, and IL-10.
Plasma concentrations of IL-6, IL-10, IL-1ra, cortisol, and adrenaline were determined using quantitative sandwich-type enzyme-linked immunosorbant assay kits (IL-6, IL10, TNF-[alpha], IL-1ra: R&D Systems, Abingdon, United Kingdom; cortisol: DRG Instruments, Marburg, Germany; adrenaline: IBL International, Hamburg, Germany) according to the manufacturers' instructions.
Researchers hope that when the non-viral gene therapy that encodes IL-10 is delivered to the spinal fluid, cells in the area will produce the body's own IL-10 and dampen pain signals.