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IL-1 |
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IL-1, abbreviation for interleukin-1. IL-1 see interleukins. IL-1 Leukocyte-activating factor An 11 kD cytokine produced by a wide range of cells; IL-1 elicits the acute phase response, acts on the CNS as a pyrogen, stimulates fibroblast, B- and T-cell proliferation and differentiation, ↑
lymphokine, collagenase and PG production, activity of NK cells against tumor targets, stimulates myocytolysis–via PGs, elicits hormone release from the pituitary, evokes the release of PMNs from the BM, and PMN degranulation, ↑ oxidase
activity and hexose monophosphate shunt activity; in synovial cells, IL-1 stimulates proliferation and production of collagen, PG, and plasminogen activator IL-1 production Stimulated by various agents–eg, calcium ionophores, IFN-α,
IFN-γ, lipopolysaccharides, muramyl dipeptide, aluminum hydroxide, phorbol myristate acetate, staphylococci, silica, and others; inhibited by corticosteroids, PGE2–via the cyclooxygenase pathway, suppressor T cells, and
cyclosporine–which specifically inhibits T cell-induced IL-1 production IL-1 & disease IL-1 may have a role in 1. Type 1 DM, ↑ IL-1
production by macrophages in the early β-cell destructive lesions of type 1 DM 2. ASHD–n-3 fish oils ↓ circulating IL-1 3. Rheumatoid arthritis–IL-1 acts with substance P IL-1 α Therapeutic uses IL-1α is reportedly effective in accelerating recovery of platelet counts after high-dose carboplatin and may be useful in thrombocytopenia induced by chemotherapy How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| IL-6 enhances IL-2 responsiveness, and IL-6 and IL-1 act in synergy to stimulate T-cell production of IL-2 (Akira et al. IL-1 Trap (rilonacept) Markedly Reduced Disease Activity in Patients with Rare Chronic Autoinflammatory Disease Food and Drug Administration (FDA) has granted fast-track designation to the IL-1 Trap program for the improvement of chronic inflammation in patients with CIAS1-Associated Periodic Syndromes (CAPS), a spectrum of rare genetic disorders. |
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