IKBKAP

(redirected from IKAP)
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IKBKAP

A gene on chromosome 9q31 that encodes a putative scaffold protein which may assemble active IKK-MAP3K14 complexes and act as subunit of the RNA polymerase II elongator complex, a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme involved in transcriptional elongation. The elongator complex may play a role in chromatin remodelling; it may be involved in acetylation of histone H3 and possibly also H4.

Molecular pathology
Defects in IKBKAP cause familial dysautonomia, also known as hereditary sensory and autonomic neuropathy type 3, or Riley-Day syndrome.
References in periodicals archive ?
Noticing a robust effect on the gene, including a jump in the production of healthy IKAP proteins, they then tested the same supplement on mouse models of FD, engineered with the same genetic mutation that causes the disease in humans.
In addition, the researchers said that the supplement's positive effects extend beyond the production of IKAP.
In an address to the first meeting of platforms builders for IKCO's new models, Rezaei also said the platforms of the auto parts for IKAP productions are ready.
IKAP has been established with the direct and equal investments by IKCO and Peugeot as part of larger a plan to produce new French vehicles inside Iran and then to export them to the regional countries.
TEHRAN (FNA)- IKCO's CEO Hashem Yekehzare appointed Mohammad Reza Motamed as the new head of the joint venture between IKCO and Peugeot named IKAP.