IGF1R


Also found in: Acronyms.

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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SemRep uses MetaMap [23] to map the text IGF1R and bladder cancer to the metathesaurus concepts "IGF1R gene" and "Carcinoma of bladder," which are associated with semantic types (or classes) "Gene or Genome" and "Neoplastic Process," respectively.
Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits.
CE decreased the expression of further genes encoding insulin-signaling pathway proteins including GSK3B, IGF1R, IGF2R, and PIK3R1.
Biomarkers such as insulin-like growth factor 1 receptor (IGF1R), phosphorylated AKT (pAKT), p-PRAS40 (T246), p-S6 (S235/236), mammalian target of rapamycin and IGF1R activity (in plasma), p53, p21, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), pAKT, pRAS, phosphatase and tensin homolog, and B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) are just a few examples of IHC markers that are requested for paraffin tissue biopsy specimens in the diagnosis of melanoma, sarcoma, and germ cell tumor in Cancer Therapy Evaluation Program trials.
Meanwhile, GH and IGF1R genes were mapped on SSC12, and many studies found that these two genes affected porcine growth and development (Wang et al.
14,15) Finally, a third mechanism of acquired resistance to EGFR tyrosine kinase inhibitors elucidated in A431 cell lines is the activation of the IGF1R pathway via IRS-1.