IGFBP3

(redirected from IGF-binding protein 3)

IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Recently we reported on the high proteolytic activity of MMP9 in juvenile idiopathic arthritis patients with low amount of IGF-binding protein 3 (IGF-BP3), possibly by impairing the reparation processes stimulated by Insulin-like Growth Factor-I (IGF-I) [10].
Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women.
Are plasma insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) useful markers of prostate cancer?
Steroid receptor coactivator 3 maintains circulating insulin-like growth factor 1 (IGF-1) by controlling IGF-binding protein 3 expression.
Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-1) and IGF-binding protein 3 (IGFBP-3).
Reference values for serum levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3 (IGFBP-3) and their ratio in Chinese adolescents.
83 *** VLC 1 P = Progesterone, IGF-I = Insulin-like growth factor I, IGFBP-3 = IGF-binding protein 3, LH = % of lean in ham, WH = Weight of ham, VLC = Valuable lean cuts, BTH = Bacon thickness, WDB = Weight of dorsal bacon, WHB = Weight of ham bacon, WTB = Weight of total bacon, SW = Slaughter weight, ADG = Average daily weight gain.
Gene expression of IGF-1, IGF-1 receptor (IGF-1R) and IGF-binding protein 3 (IGF-BP3) were quantified by real-time RT-PCR.
This might occur by an enhanced level of circulating IGF-binding protein 3 (IGF-BP3) caused by physical exercise that could antagonize IGF and reduce its mitogenic activity (Quadrilatero and Hoffman-Goetz, 2003).
Levels of IGF-binding protein 3 (IGF-BP3), the chief IGF-l-specific binding protein, are also high relative to the low GH concentrations in these patients.
WASHINGTON -- Pretreatment plasma levels of insulin-like growth factor, IGF-binding protein 3, and vascular endothelial growth factor were highly predictive of disease outcomes in a study of patients with advanced non-small cell lung cancer, Ji-Youn Han, Ph.
6 ng/mL, IGF-binding protein 3 (IGFBP-3) levels of at least 5,235 ng/mL, and vascular endothelial growth factor (VEGF) levels less than 388.