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IGF-I

   Also found in: Acronyms 0.01 sec.
IGF-I

IGF-I
Insulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarism


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[ILLUSTRATION OMITTED] Stimulating growth IGF-I is a protein that binds to receptor molecules on other cells, triggering a cascade of events that eventually stimulate cell growth.
Growth hormone release and IGF-I synthesis decrease with increasing age.
The results of both in vitro and in vivo studies suggest that elevated levels of endogenous insulin-like growth factor-I (IGF-I), observed during a 2-week endurance training of laboratory animals, increases myocardial expression of IGF-I (Scheinowitz et al.
 
 
 
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