IFRD1

IFRD1

A gene on chromosome 7q31.1 that encodes an IFN-gamma-related protein, which may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration.

Molecular pathology
IFRD1 mutations are associated with sensory/motor neuropathy with ataxia; it may also be involved in modulating the pathogenesis of cystic fibrosis lung disease.
References in periodicals archive ?
After studying nearly 3,000 cystic fibrosis patients, the team found small genetic differences in a gene called IFRD1 linked to lung disease severity.
During the analysis, the researchers discovered that the protein encoded by IFRD1 is particularly abundant in a type of white blood cell called neutrophils, and that it regulates their function.
While studying the blood samples from healthy human volunteers, the researchers found that the same IFRD1 variations that modified cystic fibrosis lung disease severity also altered neutrophil function in the healthy volunteers.
It's possible that IFRD1 itself could become a target for treatment, but right now it's a signpost to pathways for further study," Karp said.
They said a study of 3000 patients revealed levels of the gene IFRD1 varied with the severity of the disease, which destroys the lungs.
Cincinnati Children's Hospital Medical Centre in the US discovered the protein made by IFRD1 runs part of the immune system that can damage people's airways.
Study leader Dr Christopher Karp: "It's possible IFRD1 could become a target for treatment.
receptor gamma coactivator 1 NELL1 Nel(chicken)-like 1 RGS13 Regulator of G protein sgnaling 1 GDS2 GO-G1 swdch gene 2 MDK Midkine ARMET Arginine-rich mutated kr early stage tumors STX1B2 Syntaxin 1B TEX14 Testis expressed sequence 14 KHDRBS3 RNA binding KH domain Cell signaling IFRD1 Similar to Rn.