IFITM2

IFITM2

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation in a p53-independent manner.
References in periodicals archive ?
Elledge y Abraham Brass, descubrio el funcionamiento de la familia de proteinas llamada transmembrana inducida por proteinas (IFITM1, IFITM2 e IFITM3, por sus siglas en ingles) que ya se conocia desde 1984.
In this study on glioma cells, the activation of numerous interferon-induced proteins (such as IFIT1, IFIT2, IFI27, IFITM1, IFITM2, and G1P2) lends support to this mechanism of pathogenicity.
00 protein 1 (9-27) IFITM2 Interferon-induced transmembrane 3.