IFI16

IFI16

A gene on chromosome 1q22 that encodes a member of the HIN-200 (haematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines, which contain domains involved in DNA binding, transcription regulation and protein–protein interactions. IFI16 localises to the nucleus and nucleoli and interacts with p53 and retinoblastoma-1, modulating p53 function, and downregulates cell growth by the Ras/Raf signalling pathway. It is expressed in peripheral white cells (lymphoid, monocytic and myeloid precursors) and in fibroblasts.
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His lab's Science paper reveals how, during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells.
Recientemente se ha ampliado la lista con nuevas moleculas que reconocen acidos nucleicos en el citoplasma, cuyos miembros mas representativos son IFI16 (IFN-[gamma]-inducible protein Ifi16) y AIM-2 (absent in melanoma-2), que a la vez denomina esta familia como ARL (AIM2-like receptors).
Este efecto en este cancer es mediado por la estimulacion de la expresion del gen IFI16 (Interferon Gamma Inducible Gen 16).