NFKBIA

(redirected from I-kappa-B-alpha)

NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
Lately, Dyson has been working with Elizabeth Komives of the University of California, San Diego to study a duo of proteins, NF-kappaB and I-kappa-B-alpha.
On osteoclasts, icariin suppresses LPS-mediated activation of the p38 and JNK; while on the osteoblasts, icariin reduced the LPS-induced activation of ERK1/2 and I-kappa-B-alpha (I[kappa]B[alpha]), but increased the activation of p38.