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mucolipidosis[mu″ko-lip″ĭ-do´sis] (pl. mucolipido´ses)
any of a group of genetic disorders in which both glycosaminoglycans (GAGs) and lipids accumulate in tissues, but without excess of GAG in the urine.
mucolipidosis I sialidosis (type I).
mucolipidosis II a rapidly progressing disease of young children, histologically characterized by abnormal fibroblasts containing a large number of dark inclusions which fill the central part of the cytoplasm except for the juxtanuclear zone (I-cells), and clinically by severe growth impairment, minimal hepatic enlargement, extreme mental and motor retardation, and clear corneas; inherited as an autosomal recessive trait, it is due to deficiency of multiple lysosomal hydrolases. Called also I-cell disease.
mucolipidosis III a disorder similar to but milder than mucolipidosis II, and thought to be due to the same enzyme deficiency but to a lesser extent. Called also pseudo-Hurler polydystrophy.
mucolipidosis IV a form marked by early corneal clouding, psychomotor retardation, and the presence of lysosomal storage bodies; thought to be transmitted as an autosomal recessive trait.
a metabolic disorder with onset in early childhood characterized by clinical and radiographic findings similar to those in Hurler syndrome including gum hypertrophy, thoracic dysplasia, congenital hip dislocation, and mental retardation; vacuolated lymphocytes and unusual inclusion bodies in cultured fibroblasts (I-cells) are found; lysosomal enzymes are increased in serum, spinal fluid, and urine; urinary mucopolysaccharides are normal; associated with a deficiency of N-acetylglucosaminyl-1-phosphotransferase; autosomal recessive inheritance.
See mucolipidosis II.
I-cell diseaseType II mucolipidosis An AR condition caused by a defect in protein trafficking and sorting, resulting in massive accumulation of intracellular and extracellular waste products, especially glycolipids Clinical Hurler-like/type I-H mucopolysaccharidosis disease with a gargoyle face, early onset of psychomotor retardation, joint contracture, hepatosplenomegaly and cardiac decompensation, with death in childhood Lab Normal urinary mucopolysaccharides, vacuolated lymphocytes, ↑ lysosomal enzymes in serum, CSF, urine
mu·co·lip·i·do·sis II(myū'kō-lip-i-dō'sis) [MIM*252500]
see mucolipidosis II.