FABP2

(redirected from I-FABP)

FABP2

A gene on chromosome 4q28-q31 that encodes an intracellular fatty acid-binding protein that binds saturated long-chain fatty acids and is thought to play a role in triglyceride-rich lipoprotein synthesis. FABP2 may also help maintain energy homeostasis by acting as a lipid sensor; it is induced by EGF.
References in periodicals archive ?
6 When the integrity of the enterocyte membrane is compromised, I-FABP are rapidly released into the circulation.
Kittaka7 found the I-FABP level is elevated in strangulated small bowel obstruction and Wiercinska-Drapalo suggested a high level of I-FABP in ulcerative colitis,18 the two authors reported the similar viewpoints.
Results: In both CPB and 0PCAB groups, I-FABP level at the end of the operation was significantly higher than that noted at the beginning of the operation (p<0.
Conclusion: Since we have not observed any intestinal ischemia through our research, slight changes of I-FABP measurements make us believe that I-FABP would be a valuable way to monitor for intestinal ischemia in patients who undergo cardiac surgery.
Bulgular: Kardiyopulmoner baypas uygulanan grubun I-FABP duzeylerinde operasyon sonunda, baslangica gore anlamli yukselme olurken (p<0.
Sonuc: Calismamiz sirasinda hicbir hastamizda intestinal iskemi gorulmezken, I-FABP duzeylerindeki degisiklik bize acik kalp cerrahisi geciren hastalarda intestinal iskemi monitorizasyonunda I-FABP'nin kullamlabilecegini dusundurdu.
I-FABP is strongly correlated with severity of intestinal ischemia (9).
Blood samples for arterial blood gas measurements and determination of serum I-FABP levels and lAP measurements were obtained atthe beginning of surgery, end of surgery, and at 12 and 24 hour postoperatively.
In the CPB group, there was a significant drop in I-FABP from the end of the operation to each of the postoperative time points (12 hour and 24 hour, 1012.
Our study demonstrated that I-FABP levels, a strong indicator of intestinal ischemia, was elevated at the end of surgery in both CPB and 0PCAB groups.
Loss of epithelial cells from intestinal villi is correlated with plasma and urinary levels of I-FABP In both patient groups in our study.
The functions of L-FABP and I-FABP are different; the former participates in the uptake of long-chain fatty acids from digesta in the small intestine into intestinal epithelial cells, and the latter transports fatty acids from the cells to the organism (Prows et al.