Hytrin


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terazosin hydrochloride

Apo-Terazosin, Dom-Terazosin, Hytrin, Novo-Terazosin, Nu- Terazosin, PHL-Terazosin, PMS-Terazosin, Ratio-Terazosin

Pharmacologic class: Anti-adrenergic (peripherally acting)

Therapeutic class: Antihypertensive

Pregnancy risk category C

Action

Blocks postsynaptic alpha1-adrenergic receptors, causing vasodilation and decreasing smooth muscle contractions in bladder neck and prostate

Availability

Capsules: 1 mg, 2 mg, 5 mg, 10 mg

Indications and dosages

Hypertension

Adults: Initially, 1 mg P.O., increased slowly as needed up to 5 mg/day. Usual range is 1 to 5 mg/day, not to exceed 20 mg/day.

Benign prostatic hyperplasia

Adults: 1 mg P.O. at bedtime. To achieve desired response, may increase gradually to 2 mg/day, then to 5 mg/day, and then to a maximum of 10 mg/day.

Contraindications

• Hypersensitivity to drug or other quinazoline derivatives

Precautions

Use cautiously in:
• prostate cancer, hepatic disease, dehydration, volume or sodium depletion
• pregnant or breastfeeding patients
• children (safety not established).

Administration

Don't stop therapy suddenly. Dosage must be tapered.
• Know that drug may be given as a single dose at bedtime or in two divided doses.

Adverse reactions

CNS: dizziness, headache, weakness, drowsiness, nervousness, paresthesia, vertigo, fatigue, syncope

CV: orthostatic hypotension (with first dose), rebound hypertension, chest pain, palpitations, peripheral edema, tachycardia, arrhythmias

EENT: blurred vision, conjunctivitis, amblyopia, nasal congestion, sinusitis

GI: nausea, vomiting, diarrhea, abdominal pain, dry mouth

GU: urinary frequency or incontinence, erectile dysfunction, priapism

Musculoskeletal: joint, back, and extremity pain; arthritis

Respiratory: dyspnea

Skin: pruritus

Other: fever, weight gain, flulike symptoms

Interactions

Drug-drug. Estrogens, nonsteroidal anti-inflammatory drugs (NSAIDs), sympathomimetics: decreased antihypertensive effects

Midodrine: antagonism of terazosin's action

Nitrates, other antihypertensives: additive hypotension

Drug-herbs. Ephedra (ma huang): antagonism of terazosin's action

Drug-behaviors. Alcohol use: additive hypotension

Patient monitoring

• Monitor blood pressure. Stay alert for orthostatic hypotension (first-dose effect) when therapy begins.
• Assess cardiovascular status. Report chest pain, peripheral edema, palpitations, and other significant effects.

Patient teaching

• Instruct patient to take at same time every day, with or without food.

Caution patient not to stop therapy abruptly. Dosage must be tapered.

Advise patient to immediately report swelling, breathing difficulty, palpitations, chest pain, and other cardiovascular reactions.
• Tell patient drug may cause erectile dysfunction and other sexual problems.
• Caution patient not to use NSAIDs or drink alcohol.
• Instruct patient to move slowly when sitting up or standing, to avoid dizziness from sudden blood pressure decrease.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Hytrin

(hī′trĭn′)
A trademark for the drug terazosin hydrochloride.

Hytrin®

Terazosin, see there.

Hytrin

A brand name for TERAZOSIN.
References in periodicals archive ?
Last year, Hytrin ranked 28th among all prescription drugs in the United States, with sales of $387.
Abbott estimated that generic entry would displace $185 million in Hytrin sales in just 6 months.
Abbott's other key products are Biaxin, a leading broad-spectrum antibiotic, and Hytrin, a treatment for hypertension.
5 million a month not to introduce a generic version of Abbott's antihypertension medication Hytrin.
canceled a contract to delay a generic version of the former's Hytrin after the FTC began an antitrust probe earlier this year.
AB-rated, the solatol hydrochloride tablets are bioequivalent to Berlex Laboratories' Betapace, a cardiovascular drug, while the terazosin hydrochloride capsules are bioequivalent to and therapeutically interchangeable with Abbott Laboratories' prostate drug Hytrin.
United Wisconsin is currently prosecuting three other class action lawsuits concerning unfair trade practices which increased prices paid by consumers and third party payers for the prescription drugs Cardizem CD (diltiazem hydrochloride), Hytrin (terazosin hydrochloride), and Coumadin (warfarin sodium).
reached a 1998 deal involving Hytrin, a drug made by Abbott.
The product is the generic equivalent to Hytrin, an alpha-1-selective adrenoceptor blocking agent manufactured and marketed by Abbott Laboratories.
He was previously the President of Fujisawa Pharmaceutical Company and Vice President for Pharmaceutical Research at Abbott Laboratories, where he was instrumental in the development of Biaxin, Hytrin and Zileuton.