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In exposed rats, he discovered that an excess of a crucial reproductive hormone, called luteinizing-hormone-releasing hormone (LHRH), was apparently trapped in the hypothalmus.
After the hypothalmus is surgically manipulated, management includes closely monitoring body water and electrolyte balance as well as a medication regimen.
Once we have eaten enough, the hypothalmus sends out serotonin - a sedative - to tell us we've had enough.