FGF23 inhibition of the reabsorption of tubular phosphate results in intermittent hypophosphataemia
, which occurs early on in CKD.
1) CPPD can be linked to underlying metabolic disorders such as hemochromatosis, hyperparathyroidism, hypophosphataemia
, hypomagnesaemia and hypothyroidism, all of which increase the risk for calcium pyrophosphate deposition.
is a metabolic disturbance with potential serious complications and is often unrecognized in critically ill children (CIC).
These cruciferous plants were reported to be associated with hypophosphataemia
and haemoglobinuria due to their decreased phosphorous level, wider calcium to phosphorous ratio i.
2006) studied post parturient haemoglobinuric buffaloes which were treated before one year clinically and observed chronic hypophosphataemia
, decreased milk yield, lameness anoestrus and change in body color ranging from brown to light grey.
Key words: Haemoglobinuria, hypophosphataemia
, haemolytic anaemia, haemolytic syndrome, treatment of parturient haemoglobinuria, sodium acid phosphate therapy.
Hydroxylation of vitamin D in the kidney is regulated closely by parathyroid hormone (PTH), hypocalcaemia, hypophosphataemia
and is inhibited by 1,25-dihydroxyvitamin D.
Key words: haemoglobinuria, risk factors, hypophosphataemia
, haemolytic anaemia, haemolytic syndrome
Traditionally, electrolyte imbalances, such as hyper- or hyponatraemia, hyper- or hypokalaemia, and hypocalcaemia, are rapidly diagnosed and treated while hypophosphataemia
(HP) has been given less prominence.
Hypokalaemia and hypophosphataemia
are the most well described electrolyte abnormalities that may precipitate rhabdomyolysis (2).
Fanconi's syndrome consists of renal tubular acidosis, hypophosphataemia
, hypouricaemia together with urinary losses of glucose, amino acids and protein sometimes coupled with a reduced glomerular filtration rate.
Examples of metabolic disorders that may be misdiagnosed as child abuse Osteogenesis imperfecta (10) Ehlers-Danlos syndrome type IV (11) Menkes disease (12) Glutaric aciduria I (13) Secondary hyperparathyroidism (14) X-linked hypophosphataemia
(13) Epidermolysis bullosa (15) Methylmalonic academia (13) Fatty acid oxidation disorders (12)