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Hypolipoproteinemia

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Hypolipoproteinemia 

Definition

Hypolipoproteinemia (or hypolipidemia) is the lack of fat in the blood.

Description

Although quite rare, hypolipoproteinemia is a serious condition. Blood absorbs fat from food in the intestine and transports it as a combined package with proteins and other chemicals like cholesterol. Much of the fat goes straight into the liver for processing. The cholesterol, a waste product, ends up in the bile. The proteins act as vessels, carrying the other chemicals around. These packages of fat, cholesterol, and proteins are called lipoproteins.

Causes and symptoms

Low blood fats can be the result of several diseases, or they can be a primary genetic disease with other associated abnormalities.
Symptoms are associated more closely with the cause rather than the actual low blood fats.

Diagnosis

Blood studies of the various fat particles help identify both the low and high fat diseases. These tests are often done after an overnight fast to prevent interference from fat just being absorbed from food. Fats and proteins are grouped together and described by density—high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL). There are also much bigger particles called chylomicrons. Each contain different proportions of cholesterol, fats, and protein.

Treatment

Supplemental vitamin E helps children with the betalipoprotein deficiencies. There is no known treatment for Tangier disease. Treatment of the causes of the other forms of low blood fats reverses the condition.

Resources

Books

Ginsberg, Henry N., and Ira J. Goldberg. "Disorders Of Lipoprotein Metabolism." In Harrison's Principles of Internal Medicine, edited by Anthony S. Fauci, et al. New York: McGraw-Hill, 1997.

Key terms

Cholesterol — A steroid alcohol found in animal cells and fluids.
Lipoprotein — Class of proteins that contain protein and lipid. The fundamental component of living cells.

hypolipoproteinemia
the presence of lipoproteins below normal concentrations in the blood.

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