Hypogonadotropic

hypogonadotropic /hy·po·go·nado·tro·pic/ (-go-nad″ah-tro´pik) relating to or caused by deficiency of gonadotropin.

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hy·po·go·nad·o·tro·pic (hp-g-nd-trpk, -trpk)

adj.

Of or associated with inadequate secretion of gonadotropins.

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hypogonadotropic

relating to or caused by deficiency of gonadotropin.

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hypogonadism

Endocrinology 1. Inadequate gonadal function, as manifest by defects in gametogenesis, secretion of, and/or response to, gonadal hormones. Cf Androgen replacement therapy 2. A clinical condition with ↓ or absent phenotypic expression of a person's sexual genotype, which may be 1º, due to a lack of end organ response to FSH or LH produced normally by an intact pituitary gland–hypergonadotropic hypogonadism, or 2º to defective hypothalamic or pituitary hormonal activity–hypogonadotropic hypogonadism

Hypogonadism, etiology

Primary

♀ Hypergonadotropic Turner syndrome, XX Turner sydrome, XX pure gonadal dysgenesis, mixed gonadal dysgenesis, autoimmune ovarian disease

♂ Hypergonadotropic Congenital anorchia, rudimentary testes, germ cell hypoplasia–del Castillo syndrome, XY Turner phenotype–Noonan syndrome, Klinefelter syndrome and variants, XX males, XYY males

Secondary

♀ Hypogonadotropic Carpenter syndrome, hypopituitarism, Lawrence-Moon-Biedl, multiple lentigines syndrome, polycystic ovaries

♂ Hypogonadotropic Amyloidosis, Carpenter syndome, fertile eunuch syndrome, Fröhlich syndrome, Sheehan syndrome, Kallmann's disease, Laurence-Moon-Biedl disease, Lowe syndrome, Prader-Willi syndrome