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Related to hyperuricaemia: uric acid, purine

hyperuricaemia, hyperuricemia

See gout.


Enhanced blood concentrations of uric acid.
Synonym(s): hyperuricaemia.


An abnormal level of uric acid in the blood, as a result of serum urate levels that exceed the limit of solubility. This results in the deposition of crystals of monosodium urate monohydrate in joints and tendons, causing GOUT. Hyperuricaemia is most commonly due to a genetically determined defect in the excretion of urates by the kidneys.


increased blood levels of urate (i.e. >0.42 mmol/L); characteristic of chronic tophaceous gout, myeloma or cytotoxic medication; treated with allopurinol
References in periodicals archive ?
Chronic medication should be reviewed to ensure that there are no drugs that will cause hyperuricaemia.
Increased levels of uric acid are found years before the onset of symptoms, and there is no evidence to suggest that treatment is warranted for asymptomatic hyperuricaemia.
The effect of ingested purine in beer on uric acid in blood might be sufficient to augment the hyperuricaemia effect on alcohol itself producing a greater risk of gout than spirits or wine.
Tophaceous gout and high level of hyperuricaemia are both associated with increased risk of mortality in patients with gout.
It is notable in this study that the reduction in hyperuricaemia caused by treatment with 4HO-Ile is more pronounced than the reduction in hyperglycaemia, in that uric acid levels return to those of normal controls (Fig.
Her past medical history included right facial nerve palsy, a transient ischaemic attack, stable angina, hypertension, sleep apnoea treated with non-invasive assisted ventilation at night, chronic obstructive pulmonary disease, gastro-oesophageal reflux, colitis, insulin-dependent diabetes, hypo-thyroidism and hyperuricaemia.
Pan-European multicentre economic evaluation of recombinant urate oxidase (rasburicase) in prevention and treatment of hyperuricaemia and tumor lysis syndrome in haematological cancer patients.
This study was therefore carried out to evaluate the prevalence of hypercholesterolaemia, hypertriglyceridaemia, hyperuricaemia, polycythemia, and hypothyroidism in SRBD patients in Taiwan and to analyze whether there are any associations between these factors and SRBD.
It's the larger louts and the real ale crowd who'll be hobbling to the bar now, after it's been revealed it's beer and not the port and brandy that gives one hyperuricaemia.
Robbins Umeda LLP's investigation focuses on whether Ardea's board is undertaking a fair process to obtain maximum value and adequately compensate shareholders in light of the prospects for lesinurad, the company's drug in Phase III development as a potential treatment for the chronic management of hyperuricaemia in patients with gout.
Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia.
Conglomeration of hypertension, hyperglycaemia and hyperuricaemia [an association with raised triglycerides and low high density lipoprotein (HDL) cholesterol has been clearly demonstrated] is known to be associated with increased risk for cardiovascular events for almost a century (3).