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serotonin syndrome
(redirected from Hyperserotonemia)

   Also found in: Wikipedia 0.01 sec.
Serotonin syndrome
A group of symptoms caused by severely elevated serotonin levels in the body.

serotonin syndrome
Psychiatry A potentially life threatening condition caused by combined therapy with MAOIs and selective serotonin reuptake inhibitor–SSRI, antidepressants–Prozac, Zoloft, Paxil, Luvox, Wellbutrin–bupropion, tryptophan or tricyclic antidepressants, which abruptly ↑ serotonin resulting in neuromuscular, autonomic, and behavioral changes due to ↑ CNS serotonin activity Clinical Confusion, diaphoresis, ataxia, excitement, hyperthermia, hyperreflexia, myoclonus, hypotension, tremor Complications DIC, rhabdomyolisis, cardiovascular compromise Management D/C offending drug, support vital functions, dantrolene–muscle relaxant, Periactin–cyproheptadine–antihistamine, serotonin antagonist. See MAOI, SSRI.


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