Hyperimmunoglobulin E Syndrome

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An immunodeficiency disorder characterized by high plasma levels of a particular immunoglobin, a white blood cell chemotactic defect, and recurrent staphylococcal infections at various sites including the skin and upper respiratory tract. Also called Job's syndrome.

Job Syndrome

An immunodeficiency characterised by multiple recurring abscesses
Lab Defects in neutrophil and monocyte chemotaxis, increased IgE

hyperimmunoglobulin E syndrome

Hyper-IgE syndrome, Job syndrome Immunology An AR immunodeficiency characterized by chronic eczematoid lesions, recurring abscesses of skin, lungs, joints, recurring otitis media, sinusitis, life-threatening staphylococcal infections, chronic eczemoid lesions and recurring abscesses of lungs, skin, joints, eyes, ears by Staph aureus, H influenzae, S pneumoniae, group A streptococci, Candida spp Lab ↑ Eosinophils, IgE > 5000 IU/mL, ↓ antibody response to vaccines and MHC antigens, ↓ CD4:CD8–T cell helper:suppressor ratio, defects in PMN and monocyte chemotaxis, defects in PMN and monocyte chemotaxis, ↑ IgE Prognosis Prolonged survival is possible

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cold abscess
hyper-IgE syndrome
hyper-IgM syndrome
hyperimmunoglobulin M syndrome
Job Syndrome
Job's syndrome
leonine facies
leontiasis