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Hydergine

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Hydergine,
trademark for a fixed-combination drug containing various ergoloid mesylates.

Hydergine [hi´der-jēn]
trademark for preparations of ergoloid mesylates, ergot alkaloids used to combat mild to moderate dementia in the elderly.

hydergine (hīˑ·der·jēn),
n a chemical derived from ergot mold that grows on the rye grain, said to have antiaging and cognitive enhancement effects.

hydergine
Neurology A therapeutic cocktail used to alleviate some Sx of Alzheimer's disease, consisting of ergoloid mesylate–a 'metabolic enhancer,' hydergine's efficacy has not been well established. Cf Alzheimer's disease, Tacrine.


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Hydergine, NMDA receptor antagonists--others deprenyl Reduction of free radicals to lessen degenerative changes Cardiovascular risk reduction to diminish risks of dementia Eliminate heavy metal burden (e.
More stability problems appeared relating to required temperature for storage of Hydergine tablets.
Thompson, et al (N Engl J Med 1990; 323:445-8) found that Hydergine, the only drug currently FDA-approved for Alzheimer's, had no significant benefit in dementia, and may actually worsen dementia in a sub-set of patients.
 
 
 
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