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topotecan |
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topotecan /to·po·te·can/ (to″po-te´kan) an antineoplastic that inhibits DNA topoismerase; used as the hydrochloride salt in the treatment of metastatic ovarian carcinoma and small cell lung carcinoma. topotecan, an antineoplastic hormone. indication It is used to treat metastatic carcinoma of the ovary after failure of traditional chemotherapy. contraindications Factors that prohibit the use of this drug are known hypersensitivity, lactation, and severe bone marrow depression. adverse effects Life-threatening effects are neutropenia, leukopenia, thrombocytopenia, anemia, and sepsis. Other adverse effects are abdominal pain, constipation, diarrhea, obstruction, nausea, stomatitis, vomiting, increased alanine aminotransferase and aspartate aminotransferase, anorexia, arthralgia, asthenia, headache, myalgia, pain, dyspnea, and total alopecia. topotecan Hycamtin® Oncology A topoisomerase I inhibitor used for refractory ovarian CA, small cell CA, and for colorectal and breast CAs Adverse effects Dose-limiting–never if baseline neutrophils are < 1500
cells/mm3–neutropenia, anemia, thrombocytopenia; N&V, diarrhea, alopecia Contraindications Pregnancy, breastfeeding, prior BM depression. See Topoisomerase I. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Of most significance is the fact that less than 2% of cancer patients receive Hycamtin while 10% receive Paraplatin, which is used for the treatment of a variety of tumor types. The findings represent an unexpected application for Topotecan (brand name Hycamtin by GlaxoSmithKline), a drug that is currently used to treat ovarian and small cell lung cancers. has been expanded to include a co-promotion agreement wherein Coulter's sales organization will assist SB's oncology sales and marketing team with the promotion of Hycamtin and Kytril for a period of time prior to the commercial launch of Bexxar. |
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