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Huntingtin |
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Huntingtin A protein of unknown function encoded by the HD gene. The repeated CAG sequence in a defective HD gene causes the body to produce an abnormal form of huntingtin. It is not yet known why the abnormal form of huntingtin affects only certain regions of the brain. Mentioned in: Huntington Disease How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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These are triggered by the misfolding of the huntingtin protein, which clumps together if both copies of the gene which codes for it are defective. For example, dysregulated transcription has been reported in Huntington's disease, which is an inherited neurodegenerative disease caused by the expansion of polyglutamine sequences in the huntingtin protein (18). When researchers dissected the animals' brains, they found that the animals on the every-other-day diets had less atrophy and fewer clumps of the mutant huntingtin protein than the free-eaters did. |
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