monoclonal antibodies

(redirected from Humanized monoclonal antibody)
Also found in: Encyclopedia.

monoclonal antibodies

ANTIBODIES (immunoglobulins) produced by hybrid B lymphocyte tumours (myelomas). The type of antibodies produced depend on the selection of the B cell. These can be fused to cultured mouse, or even human, myeloma cells to form immortal tumours (hybridomas)-clones of cells that continue indefinitely to generate large quantities of the particular antibody produced by the B cell. The availability of quantities of almost any desired antibody has major diagnostic, therapeutic and research implications and monoclonal antibody production is one of the most important biotechnological advances of the century. Monoclonal antibodies can be made that will seek out and recognize cancers anywhere in the body, and this offers a number of intriguing possibilities for treatment. They are, however, less specific than had been initially thought, and can bind to molecules other than those intended. A serious accident occurred in a therapeutic trial in March 2206.

monoclonal antibodies

cloned (i.e. identical) antibodies

monoclonal

derived from a single cell; pertaining to a single clone.

monoclonal antibodies
identical immunoglobulin molecules formed by a single clone of plasma cells; may occur naturally in plasma cell myelomas or in vitro by the fusion of an antibody producing B lymphocyte with a non-antibody-producing myeloma B cell. The fused heterokaryon has the properties of immortality and production of a monoclonal antibody. For the most part, monoclonal antibodies are made in mouse systems.
monoclonal gammopathy
see monoclonal gammopathy.
References in periodicals archive ?
APX003/BD0801 is a humanized monoclonal antibody directed against VEGF and is under development for the treatment of multiple malignancies.
FM101 is a recombinant humanized monoclonal antibody directed against a neutralizing epitope on human IL-6.
XmAb([R])2513 is a humanized monoclonal antibody that targets the antigen CD30, a molecule expressed on the surface of a number of tumor cell types.
XmAb[R]5485 is a humanized monoclonal antibody that targets the antigen CD40 for treatment of B cell malignancies and autoimmune diseases, and contains a proprietary Xencor XmAb[R] Fc domain that enhances cytotoxic potency.
Nasdaq: ITMN) today announced that it has accepted a humanized monoclonal antibody targeted against the PcrV protein of the bacterium Pseudomonas aeruginosa.
SGN-33, or lintuzumab, is a humanized monoclonal antibody that targets the CD33 antigen that is currently in a phase I clinical trial for the treatment of AML and myelodysplastic syndromes (MDS).
Genentech) for antibodies to the antigen HER2, including Herceptin(R) (trastuzumab), Genentech's humanized monoclonal antibody for the treatment of breast cancer.
OTCBB:SMPM), a cancer stem cell company focused on in-licensing differentiated oncology compounds and anti-cancer agents, will present preclinical data on Angiolix, a humanized monoclonal antibody, that recognizes a migrating adhesion molecule called Lactadherin, at the academic community sponsored Stem Cells and Cancer conference March 2-7 in Keystone, Colorado.
Zenapax is a humanized monoclonal antibody that binds to the interleukin-2 receptor, which is expressed on activated T cells.
In the area of HIV infection, the Company is developing the viral-entry inhibitor, PRO 140, a humanized monoclonal antibody targeting the HIV coreceptor CCR5 (in phase 1b studies).
Nasdaq: MEDI) today announced it has commenced a Phase 1 clinical trial to evaluate its humanized monoclonal antibody, MEDI-493.
SGN-40 is a humanized monoclonal antibody currently in Phase I and Phase II clinical trials for multiple myeloma, chronic lymphocytic leukemia and non-Hodgkin's lymphoma.