humanize

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Related to Humanized antibodies: Chimeric Antibody

humanize

(hyo͞o′mə-nīz′)
tr.v. human·ized, human·izing, human·izes
a. To modify (a nonhuman compound, cell, organ, or organism) such that some of its components are replaced with human forms of those components, usually by means of genetic engineering.
b. To replace most of the variable region of (a monoclonal antibody from a nonhuman source) with a human sequence of amino acids so that the resulting antibody is more compatible with the human immune system.

hu′man·i·za′tion (-mə-nĭ-zā′shən) n.
hu′man·iz′er n.

humanized

(hū′mă-nīzd″)
Chemically altered to resemble natural human amino acid sequences. It applies to proteins or polypeptides derived from animals, e.g., mice, that are altered to reduce their antigenic potential.
humanize
References in periodicals archive ?
The Company is establishing a market presence in the development of humanized antibodies.
The license was granted under the terms of an agreement announced by the two companies in January 2000 covering certain intellectual property in the field of humanized antibodies, and triggers payment of an additional license fee to Protein Design.
The company is in preclinical development of humanized antibodies to P-selectin and PSGL-1 for the treatment of acute and chronic inflammatory and thrombotic disorders.
Nanoviricides creation does not require humanized antibodies, nor does it require monoclonal antibodies development.
Protein Design has a strong intellectual property position in the antibody field, with issued patents in the United States, Europe and Japan that we believe cover most humanized antibodies," said Robert L.
This enables us to offer state of the art support to pharmaceutical and drug development companies as we seek to increase antibody potency, an achievement already demonstrated with other multiple fully human and humanized antibodies.
For human medicine, cloning may be used to develop animals that secrete therapeutic proteins in their milk, that produce humanized antibodies for use as vaccines or that produce animal tissues modified for xenotransplantation.
The company acquired early funding from the United States Army in June of 2004 to explore the development of new production technologies for humanized antibodies.
The body's immune system can recognize the mouse protein found in chimeric and humanized antibodies as foreign and may launch an immune response.
The body's immune system can recognize the mouse protein found in chimeric and humanized antibodies as foreign and launch an immune response in the form of infusion reactions, allergic reactions or anaphylaxis.