host factor


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host factor

Epidemiology An intrinsic factor–age, race, sex, behaviors, etc. which influences an individual's exposure, susceptibility, or response to a causative agent
References in periodicals archive ?
In the United States and abroad, we continue to strengthen Regulus' already comprehensive patent estate relating to miR-122 compositions-of-matter and methods of use, which we believe is an important component for the commercialization of therapies targeting the host factor miR-122 to treat HCV infection.
The Lyme disease spirochete, Borrelia burgdorferi, has several known fibronectin-binding proteins, thereby suggesting importance of this host factor in a Lyme disease infection.
Integration host factor (IHF) has been shown to positively regulate expression of tcpA and ctx (17).
Cohen's team explained how the Vpu viral protein prevents the expression of Tetherin, a host factor inhibiting HIV-1 release, on the surface of infected cells.
The current meta-analysis was conducted to examine one specific host factor, mechanical ventilation, and its associated risk for Ralstonia colonization and infection.
Diabetes with poor glycemic control was the only host factor independently associated with EPN (odds ratio 4.
We continue to be encouraged by the preclinical data seen to date and believe that RG-101 has the potential to be a best-in-class host factor agent, specifically due to its pan-genotypic properties, including demonstrated efficacy in the hard to treat HCV genotype 3, and the potential for a once monthly dosing regimen.
As the protease Tmprrs2 is a host factor it is an ideal intervention point for new drugs.
Probable IFD is defined by mycological evidence in a patient with a host factor and clinical features.
In addition to a lack of protection (gloves, mask) while caring for the patient, stress may be another important host factor contributing to recurrence.
RG-101 utilizes a unique mechanism of action by targeting microRNA-122, a liver-specific host factor for stability, replication and translation of HCV.