homogentisic acid

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Related to Homogentisate: PKU

homogentisic acid

 [ho″mo-jen-tis´ik]
2,5-dihydroxyphenyl acetic acid, an intermediate product in the metabolism of tyrosine and phenylalanine, excreted in the urine in the inborn error of metabolism known as phenylketonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id),
Glycosuric acid; (2,5-dihydroxyphenyl)acetic acid; an intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in patients with alcaptonuria.
Synonym(s): alcapton, alkapton

homogentisic acid

/ho·mo·gen·tis·ic ac·id/ (ho″mo-jen-tis´ik) an aromatic hydrocarbon formed as an intermediate in the metabolism of tyrosine and phenylalanine and accumulated and excreted in the urine in alkaptonuria.

homogentisic acid

(hō′mō-jĕn-tĭz′ĭk)
n.
An intermediate of the metabolic breakdown of tyrosine and phenylalanine; it occurs in the urine in cases of alkaptonuria.

homogentisic acid

a compound that is an intermediate product of the metabolism of tyrosine. It forms a melanin-like staining substance in the urine of people who have alkaptonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id)
An intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in individuals having alcaptonuria.
Synonym(s): alcapton, alkapton.

homogentisic acid

see GARROD, A.
References in periodicals archive ?
Ochronosis is a musculoskeletal manifestation of alkaptonuria, a rare disease caused by a loss-of-function mutation on chromosome 3q, which leads to a defect in the HGO, or homogentisate 1, 2-dioxygenase enzyme.
When a patient has such a mutation, he or she manufactures a defective version of the protein homogentisate dioxygenase and, thus, suffers from alkaptonuria.
Homogentisate 1,2 dioxygenase is expressed in human osteoarticular cells: implications in alkaptonuria.