dimer

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Related to Homodimerization: dimeric, Homodimers, Heterodimerization

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

di·mer

(dī'mĕr),
A compound or unit produced by the combination of two like molecules; in the strictest sense, this occurs without the loss of atoms (thus, nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (for example, a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

dimer

/di·mer/ (di´mer)
1. a compound formed by combination of two identical molecules.
2. a capsomer having two structural subunits.

dimer

[dī′mər]
Etymology: Gk, di, twice, meros, parts
a compound formed by the union of two radicals or two molecules of a single simpler compound.

di·mer

(dī'mĕr)
A compound or unit produced by the combination of two like molecules; in the strictest sense, without loss of atoms (thus nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (e.g., a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

dimer

a molecule made by the joining of two molecules of the same kind, i.e. two MONOMERS. Ultraviolet light can induce THYMINE DIMERS in DNA.

dimer

chemical compound formed by the union of two identical molecules.
References in periodicals archive ?
HER2/neu receptor does not have a known ligand and is instead activated either by homodimerization with other HER2/neu receptors or by heterodimerization, preferentially with either EGFR or HER3.
After ligand binding, KIT undergoes homodimerization, transphosphorylation of tyrosine residues in its intracellular domain, and subsequent phosphorylation of downstream members of the RAS/RAF/MAPK, JAK/STAT, and PI3K/AKT signaling pathways, thus controlling cell proliferation, apoptosis, chemotaxis, and metabolism.
HER2 does not have a ligand and relies on heterodimerization with another family member or homodimerization with itself when expressed at very high levels to be activated.
00 am CST Abstract # 2012: Characterization of a novel proximity immunoassay for the quantitative determination of HER2 protein expression and HER2 homodimerization in formalin-fixed, paraffin-embedded breast cancer tissue.