dimer

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Related to Homodimeric: Heterodimeric, Homodimers

dimer

 
1. a compound formed by combination of two identical simpler molecules.
2. a capsomer having two structural subunits.
D-dimer a fragment of fibrin that is formed as a result of fibrin degradation. A positive test for its presence in the blood is suggestive of conditions such as thrombotic disease, sickle cell crisis, malignancy, disseminated intravascular coagulation, or recent surgery.

di·mer

(dī'mĕr),
A compound or unit produced by the combination of two like molecules; in the strictest sense, this occurs without the loss of atoms (thus, nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (for example, a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

dimer

/di·mer/ (di´mer)
1. a compound formed by combination of two identical molecules.
2. a capsomer having two structural subunits.

dimer

[dī′mər]
Etymology: Gk, di, twice, meros, parts
a compound formed by the union of two radicals or two molecules of a single simpler compound.

di·mer

(dī'mĕr)
A compound or unit produced by the combination of two like molecules; in the strictest sense, without loss of atoms (thus nitrogen tetroxide, N2O4, is the dimer of nitrogen dioxide, NO2), but usually by elimination of H2O or a similar small molecule between the two (e.g., a disaccharide), or by simple noncovalent association (as of two identical protein molecules); higher orders of complexity are called trimers, tetramers, oligomers, and polymers.
[G. di-, two, + -mer]

dimer

a molecule made by the joining of two molecules of the same kind, i.e. two MONOMERS. Ultraviolet light can induce THYMINE DIMERS in DNA.

dimer

chemical compound formed by the union of two identical molecules.
References in periodicals archive ?
Molecular masses were found to be 130 kDa and 150 kDa for the homodimeric scFv-based IgG- and IgE-analogous molecules, respectively, and 160 kDa and 190 kDa for the heterotetrameric IgG and IgE, respectively.
Compared to the conversion to entire heterotetrameric Igs (20, 21), a more convenient approach relies on the expression of homodimeric scFv-C,12-3 IgG fusions (16,19) that are easy to generate and purify and posess full binding and effector functions (19).
The following experimental observation gave important information in solving the problem of the calibrators for the Elecsys assay: The SPR binding studies of the interaction of immobilized 1[alpha]-aminoalkyl derivatives of DHT with the purified N-deglycosylated homodimeric human SHBG in solution indicated that reproducible results were obtained only in a concentration range of 10-200 nmol/L.
3 for one representative individual serum, the broad peak in the high-molecular-mass range (~1000 kDa) in addition to the characteristic peak of the homodimeric protein indicates the presence of high-molecular-mass aggregates.
Binding analysis of 1a- and 17[alpha]-dihydrotestosterone derivatives to homodimeric sex hormone-binding globulin.
8) have described ELISAs with tetramethylbenzidine for total OPG and the homodimeric form of OPG (detection range for both ELISAs, 65-500 ng/L).
Monomeric and homodimeric forms of recombinant hOPG (rhOPG), monoclonal antibodies OI-4 and OI-19 (specific for both forms of rhOPG), and monoclonal antibody OI-26 (specific for the homodimeric form) were prepared as reported previously (8).
However, our ELISA with the OPD colorimetric method did not detect the homodimeric form in samples from either controls or patients, because the concentrations of OPG were below the detection limit (125 ng/L).
We next performed immuno-PCR for the homodimeric form of hOPG, according to the method described previously (9).
5, 5, 10, 25, 50, and 100 pg/L) of the homodimeric form of rhOPG were used.
To study specificity, monomeric or homodimeric rhOPG was dissolved at a final concentration of 50 pg/L in diluted human serum (control).
10), homodimeric OPG may exert more potent biologic activity than the monomeric form.